{"id":157,"date":"2013-10-24T11:17:51","date_gmt":"2013-10-24T16:17:51","guid":{"rendered":"http:\/\/agrilife.org\/jjgill\/?p=157"},"modified":"2013-10-24T11:17:51","modified_gmt":"2013-10-24T16:17:51","slug":"sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans","status":"publish","type":"post","link":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/","title":{"rendered":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans?"},"content":{"rendered":"

The global epidemic of multidrug-resistant Salmonella<\/em> Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.<\/p>\n

 <\/p>\n

Science | Sources of Antimicrobial Resistance (Perspective)<\/a><\/p>\n

Science | Distinguishable Epidemics of Multidrug-Resistant Salmonella<\/em> Typhimurium DT104 in Different Hosts<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and… Read More →<\/a><\/span><\/p>\n","protected":false},"author":830,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-157","post","type-post","status-publish","format-standard","hentry","category-in-the-literature"],"acf":[],"yoast_head":"\nSources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab\" \/>\n<meta property=\"og:description\" content=\"The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and... Read More →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/\" \/>\n<meta property=\"og:site_name\" content=\"Gill Lab\" \/>\n<meta property=\"article:published_time\" content=\"2013-10-24T16:17:51+00:00\" \/>\n<meta name=\"author\" content=\"jason.gill\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jason.gill\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/\"},\"author\":{\"name\":\"jason.gill\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/#\\\/schema\\\/person\\\/0889212d914dfda49386f91af1ed1b00\"},\"headline\":\"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans?\",\"datePublished\":\"2013-10-24T16:17:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/\"},\"wordCount\":178,\"articleSection\":[\"In the literature\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/\",\"url\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/\",\"name\":\"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/#website\"},\"datePublished\":\"2013-10-24T16:17:51+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/#\\\/schema\\\/person\\\/0889212d914dfda49386f91af1ed1b00\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/#website\",\"url\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/\",\"name\":\"Gill Lab\",\"description\":\"Bacteriophage biology and application\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/#\\\/schema\\\/person\\\/0889212d914dfda49386f91af1ed1b00\",\"name\":\"jason.gill\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g\",\"caption\":\"jason.gill\"},\"url\":\"https:\\\/\\\/agrilife.org\\\/jjgill\\\/author\\\/jason-gill\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/","og_locale":"en_US","og_type":"article","og_title":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab","og_description":"The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and... Read More →","og_url":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/","og_site_name":"Gill Lab","article_published_time":"2013-10-24T16:17:51+00:00","author":"jason.gill","twitter_card":"summary_large_image","twitter_misc":{"Written by":"jason.gill","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/#article","isPartOf":{"@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/"},"author":{"name":"jason.gill","@id":"https:\/\/agrilife.org\/jjgill\/#\/schema\/person\/0889212d914dfda49386f91af1ed1b00"},"headline":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans?","datePublished":"2013-10-24T16:17:51+00:00","mainEntityOfPage":{"@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/"},"wordCount":178,"articleSection":["In the literature"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/","url":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/","name":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans? - Gill Lab","isPartOf":{"@id":"https:\/\/agrilife.org\/jjgill\/#website"},"datePublished":"2013-10-24T16:17:51+00:00","author":{"@id":"https:\/\/agrilife.org\/jjgill\/#\/schema\/person\/0889212d914dfda49386f91af1ed1b00"},"breadcrumb":{"@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/agrilife.org\/jjgill\/sources-of-antimicrobial-resistance-are-animals-a-major-reservoir-of-resistance-in-humans\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/agrilife.org\/jjgill\/"},{"@type":"ListItem","position":2,"name":"Sources of Antimicrobial Resistance: Are Animals a Major Reservoir of Resistance in Humans?"}]},{"@type":"WebSite","@id":"https:\/\/agrilife.org\/jjgill\/#website","url":"https:\/\/agrilife.org\/jjgill\/","name":"Gill Lab","description":"Bacteriophage biology and application","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/agrilife.org\/jjgill\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/agrilife.org\/jjgill\/#\/schema\/person\/0889212d914dfda49386f91af1ed1b00","name":"jason.gill","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f6ac5eb4fbc8af60ab74f5b5621fd3a7a70c1eeb8d9d9b699628ced58a8d6406?s=96&d=mm&r=g","caption":"jason.gill"},"url":"https:\/\/agrilife.org\/jjgill\/author\/jason-gill\/"}]}},"_links":{"self":[{"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/posts\/157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/users\/830"}],"replies":[{"embeddable":true,"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/comments?post=157"}],"version-history":[{"count":0,"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/posts\/157\/revisions"}],"wp:attachment":[{"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/media?parent=157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/categories?post=157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agrilife.org\/jjgill\/wp-json\/wp\/v2\/tags?post=157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}