{"id":196,"date":"2017-12-14T14:14:29","date_gmt":"2017-12-14T14:14:29","guid":{"rendered":"http:\/\/soilcrop.tamu.edu\/latest-crop-improvement-technology-coming-to-texas-am-agrilife\/"},"modified":"2018-12-17T16:59:15","modified_gmt":"2018-12-17T16:59:15","slug":"latest-crop-improvement-technology-coming-to-texas-am-agrilife-soilcrop-tamu-edu","status":"publish","type":"post","link":"https:\/\/agrilife.org\/cgel\/2017\/12\/14\/latest-crop-improvement-technology-coming-to-texas-am-agrilife-soilcrop-tamu-edu\/","title":{"rendered":"Latest Crop Improvement Technology Coming to Texas A&M AgriLife"},"content":{"rendered":"
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COLLEGE STATION \u2013 Texas A&M AgriLife Research is investing in the future of rapid crop design with improved traits through the deployment of two new labs and a half-million dollar seed grant program to jump-start the process.<\/p>\n
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\"Charlie<\/p>\n

Dr. Charlie Johnson, director of the Genomics and Bioinformatics Service Lab, College Station. (Texas A&M AgriLife photo)<\/p>\n<\/div>\n

\u201cWe are pleased to announce a new funding opportunity that focuses on building a pipeline for genome editing in agriculturally important crops in Texas and beyond,\u201d said Dr. Bill McCutchen, executive associate director of AgriLife Research, College Station.<\/p>\n

\u201cThe recent development of the Crop Genome Editing Lab and the MultiCrop Transformation Lab, coupled with the existing capabilities of the Genomics and Bioinformatics Service Lab, uniquely positions us to research and discover novel methods and solutions for important traits across multiple crops,\u201d McCutchen said.<\/p>\n

Together, these research and service labs, combined with one of the largest agriculture-focused sequencing facilities in the world, can now provide a complete plant genome editing pipeline for crop improvement, said Dr. Charlie Johnson, director of the Genomics and Bioinformatics Service Lab, College Station.<\/p>\n

The Crop Genome Editing Lab is led by Dr. Michael Thomson, Texas\u00a0A&M University professor and HM Beachell Rice Chair with AgriLife Research, while the MultiCrop Transformation Lab is directed by research specialists Marco and Mayra Molina.<\/p>\n

\u201cWe believe our 25-plus years combined experience working on plant biotechnology, either on academia or industry will fully support AgriLife\u2019s initiative of building this pipeline aimed at successful plant transformation of major commercial crops and overcoming challenges such as stable transformation and plant regeneration,\u201d the Molina\u2019s said in a joint statement.<\/p>\n

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\"Dr.<\/p>\n

Dr. Michael Thomson, Texas A&M University professor and HM Beachell Rice Chair with AgriLife Research. (Texas A&M AgriLife photo)<\/p>\n<\/div>\n

Some of the newest capabilities include genomics analysis for single guide RNA design, Cas9\/sgRNA construct development, biolistic or Agrobacterium-based transformation, plant regeneration and confirmation of gene-edited progeny.<\/p>\n

Thomson said by working with individual research and breeding groups, their combined expertise can help jump-start genome editing activities for crop improvement.<\/p>\n

The seed grant program will fund approximately 20 projects focused on a specific crop, trait and target gene or genes, with each project allowed to request up to $30,000 in service credits for the entire project, he said.<\/p>\n

The seed grant program aims to link investigators with this integrated genome-editing pipeline to test genome editing approaches for their target crop and trait.<\/p>\n

\u201cWe are now utilizing CRISPR\/Cas9 genome editing, which has transformed research approaches across a wide range of fields,\u201d Thomson said. \u201cThis method presents an unprecedented opportunity to rapidly deploy beneficial traits in major crops, thus cutting time off the long breeding process.\u201d<\/p>\n

While genome editing offers tremendous promise, Thomson said there are still a number of challenges to be tackled before the technology becomes routinely used for crop improvement.<\/p>\n

Some of the issues for researchers will be:<\/p>\n

\u2013 Knowing the gene or genes underlying the trait of interest.<\/p>\n

\u2013 Targeting multigene families or genes in polyploid species.<\/p>\n

\u2013 Moving beyond simple knock-outs to implement precise base edits and allele replacements.<\/p>\n

\u2013 Avoiding off-target effects.<\/p>\n

\u2013 Overcoming genotype-specific transformation.<\/p>\n

\u2013 Regeneration constraints.<\/p>\n

\u2013 Efficiently selecting progeny with the desired edits.<\/p>\n

\u201cWe have this technology and we are open for business,\u201d Johnson said. \u201cThis is part of AgriLife Research\u2019s continued investment into agriculture and life science platforms and providing the latest technology and corresponding seed grants to our faculty.\u201d<\/p>\n<\/section>\n

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